Dr Mohd Farooq Shaikh

Contact Details

Tel: +603 5514 4483
Fax: +603 5514 6323
Office: Room 4-4-57
Email: farooq.shaikh@monash.edu

Profile Summary

Dr Mohd. Farooq Shaikh joined Monash University Malaysia in March 2013, where he is actively involved in neuropharmacological research. His personal interest is experimental epilepsy and the discovery of anti-epileptic drugs from diverse sources including medicinal plants. His research approach involves pharmacology, biochemistry, behavior and gene expression techniques using in-silico, in-vitro and in-vivo studies in collaboration with national and international researchers. Currently his team is working on epilepsy and Alzheimer’s disease related cognitive dysfunctions like learning and memory.

Dr Farooq completed his PhD in Pharmacology from the Institute of Chemical Technology, University of Mumbai, India, in 2012. During his PhD (2011), he was also selected by the International Brain Research Organization (IBRO) to be part of the prestigious Young Scientist Training Program for his research work in epilepsy. In 2012, he was awarded the IBRO-APRC fellowship to continue his post-doctoral studies at School of Biomedical Sciences, University of Queensland, Australia, where he worked with Dr. Karin Borges on epilepsy therapy research. Dr Farooq has successfully executed several research projects for reputable pharmaceutical companies in Mumbai, such as Glenmark Generics, Advanced Enzymes, Charak Pharma, and Dr. Palep’s Medical Research Foundation.

 

Awards and Distinctions

  • Awards and Distinctions
  • International Brain Research Organization-Asia Pacific Regional Committee (IBRO-APRC) Exchange Fellowship Award for the year 2012.
  • International Young Investigator Fellowship for the year 2011 from IBRO.
  • Senior Research Fellowship from Indian Council of Medical Research (ICMR), Ministry of Health and Family Welfare, Govt. of India (2010-2012).
  • Junior Research Fellowship from UGC-Maulana Azad National Fellowship, Ministry of Minority Affairs, Govt. of India (2009-2010).
  • Research Scholarship from Dr. Palep’s Medical Research Foundation, India (2008).

Qualifications

B. Pharm. (RGUHS, Bangalore), M. Pharm. (Pharmacology) (RGUHS, Bangalore), PhD. Tech. (Pharmacology) (Institute of Chemical Technology, Mumbai)

Professional Affiliations

  • Member, International Brain Research Organization (IBRO)
  • Life Member, Malaysian Society of Neuroscience (MSN)
  • Life Member, Malaysian Epilepsy Society (MES)
  • Member, Malaysian Society of Physiology and Pharmacology (MSPP)
  • Registered Pharmacist, Maharashtra State Pharmacy Board

 

Research Interests

Neuropharmacology, experimental epilepsy and cognitive dysfunction

 

Research Grants Awarded

MOSTI (Ministry of Science, Technology and Innovation, Malaysia) eScience Research Fund-2014-2017
Project title: Embelin, a Malaysian plant derived benzoquinone in the treatment of epilepsy induced cognitive dysfunction.
Role: Principal Investigator,
Grant amount: RM 166,000

NKEA RESEARCH GRANT SCHEME (NRGS) MINISTRY OF AGRICULTURE AND AGRO-BASED INDUSTRY, MALAYSIA-2014-2017
Project title: Evaluations of neuroprotective activity of standardized ethanolic Orthosiphon stamineus extract ameliorate cognitive alterations in Alzheimer’s disease. Role: Co-investigator
Grant amount: RM 420,000

NKEA RESEARCH GRANT SCHEME (NRGS) MINISTRY OF AGRICULTURE AND AGRO-BASED INDUSTRY, MALAYSIA-2014-2017
Project title: Elucidating the anti-neuroinflammatory effect of Clinacanthus nutans on Lipopolysaccharide-induced neurotoxicity in BV2 cells and rat.
Role: Co-investigator, 
Grant amount: RM 400,000

ECR seed grant (2014), MONASH University Malaysia
Project title: Evaluations of neuroprotective activity of standardized ethanolic Orthosiphon stamineus extract ameliorate cognitive alterations in Alzheimer’s disease. Role: Principal Investigator 
Grant amount: RM 30,000

Research Supervision

  1. Student Name: Alexis, Chung Yin Sir, (PhD, 2016-2019): Main Supervisor
    Project Title: Investigation of biological actions on satiety in reward circuit of Orthosiphon stamineus Benth
  2. Student Name: Uday Kundap, (PhD, 2015-2018): Main Supervisor
    Project title: Role of Embelin in epilepsy induced cognitive deficit in zebrafish model.
  3. Student Name: Thaarvena Retinasamy, (PhD, 2015-2018): Main Supervisor
    Project title: Evaluation of neuroprotective activity of standardized ethanolic Orthosiphon stamineus extract to ameliorate cognitive alterations in Alzheimer’s disease.
  4. Student Name: Saatheeyavaane B., (PhD, 2015-2018): Main Supervisor
    Project title: Neuroprotective effect of Embelin in an experimental model of Alzheimer’s disease.
  5. Student Name: Jing Ying, (B. Sc. (Honors), 2015, completed): Co-supervisor
    Project title: Effect of medicinal plant in animal models of infertility.
  6. Student Name: Alina Arulsamy, (B. Sc. (Honors), 2014, completed): Co-supervisor
    Project title: Pharmacological Evaluation of Leucaena leucocephala (Petai Jawa) in Anxiety and Depression.

 

Publications

  1. Kundap, U., Jaiswal, Y., Sarawade, R., Williams, L. and Shaikh, M.F., 2016. Effect of Pelargonidin isolated from Ficus benghalensis L. on phenotypic changes in zebrafish (Danio rerio) embryos. Saudi Pharmaceutical Journal. (In press)
  2. Jing Ying Hoo, Yatinesh Kumari, Mohd. Farooq Shaikh, Seow-Mun Hue, and Goh Bey Hing. Zebrafish: a versatile animal model for fertility research. BioMed Research International .(2016) (in press).
  3. Arulsamy A, Kumari Y, Shaikh MF. Reverse Pharmacology: Fast Track Path of Drug Discovery. Pharm Pharmacol Int J 4(3): 00077 (2016).
  4. Sayyad, M., Ning, T., Kumari, Y., Hing, G.B., Jaiswal, Y., Rosli, R., Williams, L. and Shaikh, M.F. Acute toxicity profiling of the ethyl acetate fraction of Swietenia macrophylla seeds and in-vitro neuroprotection studies. Saudi Pharmaceutical Journal. (In press) (2016)
  5. A Arulsamy, MF Shaikh. Impact of epilepsy on the manifestations of anxiety disorders. International Journal of Nutrition, Pharmacology, Neurological Diseases 6:3-11, (2016).
  6. Qiang Ying Tan, Uday P Kundap, Yatinesh Kumari, Mohd. Farooq Shakh, A Review on Natural Therapy for Seizure Disorders. Pharm Pharmacol Int J, 3(2): 00051 (2015).
  7. A Arulsamy, BH Goh, MF Shaikh. Current status of epilepsy in Malaysia and way ahead. Int J Pharm Pharm Sci, Vol 7, Issue 1, 2-5 (2015).
  8. Mateen Sayyed, MF Shaikh, Aziz-ur-Raheman1, Jabeen, Syed YH. Pathophysiological and therapeutic approaches of cachexia: A silent & progressive killer accompanied with cancer. Int J Adv Pharmacy Med Bioallied Sci. 2, 1, 2014.
  9. J Sancheti1, MF Shaikh, M Akhade, FA Shaikh, S Sathaye. Nutritional therapy for epilepsy. Journal of Pharmaceutical and BioSciences 1(4), 149-156 (2013).
  10. J Sancheti, MF Shaikh, PF Khatwani, SR Kulkarni, S Sathaye. Development and validation of a HPTLC method for simultaneous estimation of L-glutamic acid and γ-aminobutyric acid in mice brain. Indian Journal of Pharmaceutical Sciences, 75(6), 716-721 (2013).
  11. MF Shaikh, KN Tan, K Borges. Anticonvulsant screening of luteolin in four mouse seizure models. Neuroscience Letters 55, 195-199, (2013).
  12. J Sancheti, MF Shaikh, R Chaudhari, G Somani, S Patil, P Jain, S Sathaye. Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models. Naunyn-Schmiedeberg's Archives of Pharmacology, (2013), 1-8.
  13. MF Shaikh, J Sancheti, S Sathaye. Effect of Eclipta alba on acute seizure models: a GABAA-mediated effect. Indian Journal of Pharmaceutical Sciences, 75(3), 380-384 (2013).
  14. MF Shaikh, J Sancheti, S Sathaye. Phytochemical and Pharmacological investigations of Eclipta alba (Linn.) Hassak leaves for antiepileptic activity. International Journal of Pharmacy and Pharmaceutical Sciences, 4 (4), 319-323 (2012).
  15. Y Jaiswal, MF Shaikh, R Kenjale, G Talele, Application of HPTLC for Simultaneous Estimation of Ambroxol hydrochloride and Roxithromycin in Pharmaceutical Dosage Forms. Eurasian Journal of Analytical Chemistry 7( 3), (2012).
  16. S Sathaye, VB Mehta, MF Shaikh, PD Amin. Preventive and curative effect of Lagenaria vulgaris in NSAID induced ulcer model. International Journal of Research in Pharmaceutical Sciences, 2(1), 2011, 88-91.
  17. R Kenjale, MF Shaikh, S Sathaye. Evaluation of Hepatoprotective Effect of Polyherbal Formulation–Livomyn. International Journal of Research in Pharmaceutical Sciences, 2(3), 2011, 338-343.
  18. VB Mehta, VJ Sharma, MF Shaikh, PD Amin, S Sathaye. Evaluation of Antioxidant and Immunomodulatory activity of Lagenaria vulgaris. International Journal of Research in Pharmaceutical Sciences, 2(3), 2011, 393-398.
  19. MF Shaikh, T R Alla, NV Rao, K Prasad, Shalam, K Nandakumar, T S Gouda, S Satyanarayana. A study on CNS effects of milk extract of nuts of Semecarpus anacardium, Linn.(Anacadiaceae). Pharmacologyonline 1: 49-63 (2007).
  20. MF Shaikh, S Sathaye and NV Rao. Anticonvulsant activity of milk extract of nuts of Semecarpus anacardium, Linn. Advances in Pharmacology and Toxicology 10(1), 67-69 (2009).
  21. S Sathaye, D Shah, MF Shaikh. Reverse Pharmacology: An economic tool for drug discovery. Pharma Beats Magazine 6-8 (2008).

 

 

Book /Book Chapters

  1. Book Chapter: MF Shaikh, LL Williams (2016-2017), Hypertension: Pharmacology of Antihypertensives. Recent Progress in Medicinal Plants: Metabolic disorders. Vol. 2. Studium Press LLC, Houston, USA.  (In press).
  2. Book Chapter: MF Shaikh, LL Williams (2016-2017), Hyperlipidemia: Pharmacology of Antihypertensives. Recent Progress in Medicinal Plants: Metabolic disorders. Vol. 2. Studium Press LLC, Houston, USA.  (In press).

 

Abstracts

  1. Uday P Kundap, Yatinesh Kumari, Iekhsan Othman, Mohd. Farooq Shaikh. Embelin, a potential molecule to ameliorate seizure induced cognitive decline in T-maze zebrafish model. European Neuropsychopharmacology, 2016, 26, S273-S274. DOI: 10.1016/S0924-977X(16)31159-2.
  2. Kundap UP, Bhuvanendran S, Kumari Y and Shaikh MF (2016). Development of a zebrafish model for epilepsy and antiepileptic drugs induced cognitive dysfunction. Front. Cell. Neurosci. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00169.
  3. Bhuvanendran S, Kumari Y, Othman I and Shaikh MF (2016). Memory enhancing effect of embelin against scopolamine-induced amnesia in Sprague Dawley rats. Front. Cell. Neurosci. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00164.
  4. Retinasamy T, Kumari Y, Othman I and Shaikh MF (2016). Orthosiphon stamineus improves disturbances of learning, recognition memory and spatial long-term memory in scopolamine-induced amnesia in rats. Front. Cell. Neurosci. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00189.
  5. Mohd. Farooq Shaikh, Zurina Hassan, Yatinesh Kumari, Amin Malik Shah A M, Iekshan Othman. Orthosiphon Stamineus Improve Memory and Hippocampal Long Term Potentiation Impairment in a Chronic Cerebral Hypoperfusion Model in Rat. Cerebrovascular Diseases 42(suppl 1):152 • July 2016. DOI: 10.1159/000447732.
  6. Uday P Kundap, Yatinesh Kumari, Iekhsan Othman, Nafees Ahmed, Mohd. Farooq Shaikh. Embelin’s affinity towards GABAA receptor and the ability to modulate neurotransmitters makes it an anticonvulsant compound. 20th Thai Neurosciences Society International Conference, July 2016, at Naresuan University Phitsanulok, Thailand,
  7. Mohd. Farooq Shaikh, Discovery of Anticonvulsants using Reverse Pharmacology: A Fast Track Pathway” is delivered at the 1st International Conference Of Pharmacy And Health Sciences 2016 18th – 20th March 2016, Hotel Casuarina @ Meru, Ipoh, Malaysia.
  8. Uday P Kundap, Tiang Ning, Yatinesh Kumari, Iekhsan Othman, Mohd. Farooq Shaikh. Cognitive Dysfunctioning By Epilepsy & AEDs In Zebrafish Model. Malaysia Zebrafish Disease Models held at Cancer Research Malaysia, SJMC, Malaysia, 11-12 Nov. 2015.
  9. Tharveena Retinasamy, Saatheeyavaane Bhuvanendran, Mohd. Farooq Shaikh, Yatinesh Kumari, Iekshan Othman, Goh Bey Hing, Amin Malik Shah A M, Aman Shah A M, Zurina Hassan. The Effect of Ethanolic Orthosiphon stamineus Extract on Learning & Memory in Chronic Cerebral Hypoperfusion Induced Cognitive Impairment in Rats. CDR Mini Symposium on Drug Addiction and Neurodegeneration to be held from the 4th - 6th November 2015 at Auditorium Ishak Pateh Akhir, Sains@USM, Bukit Jambul, Penang.
  10. Saatheeyavaane Bhuvanendran, Tharveena Retinasamy, Mohd. Farooq Shaikh, Yatinesh Kumari, Iekshan Othman, Zurina Hassan. Pharmacological evaluation of phytocompound Embelin, derived from Embelia ribes in Alzheimer’s disease using chronic cerebral hypoperfusion rats. CDR Mini Symposium on Drug Addiction and Neurodegeneration to be held from the 4th - 6th November 2015 at Auditorium Ishak Pateh Akhir, Sains@USM, Bukit Jambul, Penang.
  11. MF Shaikh, Iekhsan Othman. Neuroproteomics: A Guiding Light for Neurodegenerative Diseases’ Therapy”. CDR Mini Symposium on Drug Addiction and Neurodegeneration to be held from the 4th - 6th November 2015 at Auditorium Ishak Pateh Akhir, Sains@USM, Bukit Jambul, Penang.
  12. Y Kumari, BH Goh, MF Shaikh. Piper betel,a novel melatonin agonist for the treatment of sleep disorder. International Conference on Biomedical & Health Sciences Research 2015, Putrajaya, Malaysia (25-27 January 2015).
  13. MF Shaikh, S Sathaye. Anticonvulsant Activity of Eclipta alba using Experimental Models of Epilepsy. Epilepsia 52, 262, 2011.
  14. MF Shaikh, S Sathaye. Anitconvulsant activity of Eclipta alba using experimental models of epilepsy. 8th IBRO World Congress of Neuroscience, Florence, Italy (July 14-18 2011).
  15. R Kenjale, D Vithlani, V Sharma, MF Shaikh, D Shah, H Shete, S Sathaye. Anti-oxidant activity of dried seeds of Trigonella foenumm (fenugreek), Nigella sativa (black cumin) and Linum lusitatissimum (linseed) and dried ripe fruits of Trachyspermum copticum (ajowan), Indian Journal Of Pharmacology, 40, 223, 2008
  16. HK Shete, DP Shah, MF Shaikh, SS Sathaye. Kajjali, an ayurvedic herbomineral preparation, accelerates the gastric emptying in experimental sprague dawley rats, Indian Journal Of Pharmacology, 40, 223-224, 2008
  17. MF Shaikh, R Kenjale, D Shah, S Sathaye, N Rao. Anticonvulsant activity of milk extract of nuts of Sememcarpus anacardium, linn. Indian Journal Of Pharmacology, 40, 88, 2008.
  18. MF Shaikh, N Patel, K Nandakumar, NV Rao. Analgesic and Antiinflammatory activity of Alcoholic and Aqueous extracts of roots of Tylophora indica (Asclepiadaceae). Association of Pharmaceutical Teachers of India (APTI)-11th Annual National Convention 2006, NIMHANS, India (Sept. 1-3, 2006).
  19. MF Shaikh, M Yadav, K Nandakumar, NV Rao. “A study on drug-drug interaction between loperamide and α2-adrenoreceptor agonists”. 58th Indian Pharmaceutical Congress, Mumbai (Dec. 1-3, 2006).